منابع مشابه
Heat shock proteins and hypometabolism: adaptive strategy for proteome preservation
Correspondence: Kenneth Storey Departments of Biology and Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6 Tel +1 613 520 3678 Fax +1 613 520 3749 email [email protected] Abstract: To survive under harsh environmental conditions many organisms retreat into hypometabolic states where metabolic rate may be reduced by 80% or more and energy use is repriori...
متن کاملChanges in the serum proteome of patients with sepsis and septic shock.
BACKGROUND Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28. METHODS We applied proteomic technology to serum samples of patients with sepsis and septic shock. Serum samples from 18 patients with sepsis and septic shock were obtained during the f...
متن کاملPlasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers.
One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients. Here we report that a Plasmodium Asn repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at febrile temperatures, as did a yeast Asn/Gln-rich protein (Sup35). Co-expression ...
متن کاملProteome analysis in the study of the bacterial heat-shock response.
In recent years, it has become clear that, in addition to the regulation of the expression of specific genes, there are global regulatory systems that control the simultaneous expression of a large number of genes in response to a variety of environmental stresses. The first of these global control systems, and of substantial importance, is the heat-shock response. The heat-shock response is ch...
متن کاملHeat shock proteome of Agrobacterium tumefaciens: evidence for new control systems.
The regulation of Agrobacterium tumefaciens heat shock genes involves a transcriptional activator (RpoH) and repressor elements (HrcA-CIRCE). Using proteome analysis and mutants in these control elements, we show that the heat shock induction of 32 (out of 56) heat shock proteins is independent of RpoH and HrcA. These results indicate the existence of additional regulatory factors in the A. tum...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2002
ISSN: 1474-760X
DOI: 10.1186/gb-2002-3-6-reports0030